3-hydroxyanthranilate oxidase
| 3-hydroxyanthranilate oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.10.3.5 | ||||||||
| CAS no. | 37256-53-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
3-hydroxyanthranilate oxidase (EC 1.10.3.5) (also called 3-HAO) is an enzyme that catalyzes the chemical reaction:[1]
The two substrates of this enzyme are 3-hydroxyanthranilic acid and oxygen. Its products are 6-imino-5-oxocyclohexa-1,3-dienecarboxylic acid and hydrogen peroxide.[2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with oxygen as acceptor. The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen oxidoreductase. This enzyme is also called 3-hydroxyanthranilic acid oxidase.
References
- ^ Vécsei, L; Szalárdy, L; Fülöp, F; Toldi, J (January 2013). "Kynurenines in the CNS: recent advances and new questions". Nature Reviews. Drug Discovery. 12 (1): 64–82. doi:10.1038/nrd3793. PMID 23237916.
- ^ Enzyme 1.10.3.5 at KEGG Pathway Database.
- ^ Morgan LR Jr, Weimorts DM, Aubert CC (1965). "Oxidation Of 3-hydroxyanthranilic acid by a soluble liver fraction from poikilothermic vertebrates". Biochim. Biophys. Acta. 100 (2): 393–402. doi:10.1016/0304-4165(65)90008-5. PMID 14347936.